Lexington Regional Health Center opened as Tri-County Hospital in September of 1976. The hospital began with seven patients, 40 beds, five physicians, one PA, a board-certified surgeon, and visiting specialists.

The organization grew through the 1980s and added additional services including radiology, therapy, rehabilitation, and hospice. A 4,300 square-foot expansion in 1989 relocated six physical therapy rooms, added a meeting room, and included an area for wellness programs for the community. The addition of Home Health Care services, which encompasses a 45-mile radius of Lexington, Nebraska, was completed in 1994. Another expansion in 1996 provided more room for the physical therapy department with the opening of the Community Health & Fitness Center. In 2005, Tri-County Hospital was designated as a Critical Access Facility by the State of Nebraska.

The year 2011 marks the transition from Tri-County Hospital to Lexington Regional Health Center. In the first 35 years of operation the facility has expanded to offer a wide range of services and additional staff and specialists. Over the years, the rehabilitation department, outpatient services, and the radiology department, among other departments, have increased their services to better serve the needs of our community. The opening of Urgent Care in the fall of 2011 has further expanded the services offered.